Strategies specifically targeting CSC surface markers such as CD44 have been explored successfully in leukemia and breast cancer in pre-clinical models.
Indeed, that is a space that has been explored by a number of others, some successfully and others not so much, so staying away from that moving target, and focusing instead on delivering strong fashion editorial, is perhaps the best way of remaining distinct.
Encapsulation strategies of non metal-containing drugs within ferritin cages have been explored and successfully performed with encouraging results.
Over the years, the opportunities of this computing paradigm have been explored and the benefits have been exploited successfully in many application fields.
Coupling of nitric oxide, a cellular antioxidant with NSAIDs has also been explored successfully to design anti-inflammatory agents with markedly reduced ulcerogenic potential 4, 9. Coumarins form an elite class of compounds, which exhibit a variety of therapeutic activities including antioxidant, anti-inflammatory, antitumor, antiviral, antituberculosis and antimicrobial 10, 11, 12, 13.
This approach of reducing the rate of defluorination in vivo has been previously explored successfully in our group for the synthesis of the norepinephrine transporter radioligand [18F]FMeNER-D2 [14] and the cannabinoid subtype-1 radioligand [18F]FMPEP-d2 [15].
