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This concept cannot be proven at the moment, because the data available have been driven essentially by historical opportunity: anti-TNF were the first to become available and for that reason they became first line, and the alternatives used upon their failure.
The ability to perform such manipulations in essentially any organism has been driven by the use of nucleases that can be targeted to specific sites within the genome in a predictable manner (reviewed by Gaj et al., 2013).
Mozoo is essentially self-funded and growth has been driven by profitability.
The growth in the number of biomedical Ph.D.s over the last several years has been driven almost entirely by foreign students; the number of American students earning biomedical Ph.D.s has been essentially flat.
Having been driven just 15 miles, it was essentially new.
Moreover, many of those in the forefront of progressive political change, who have abandoned religion, have been driven by a humanism that has been essentially built up by our Christian heritage as Charles Taylor has recently brought out in his magisterial study, A Secular Age.
I have been driven to succeed.
Deer have been driven into villages.
I have been driven to own something.
M had been driven mad by grief.
Thousands have been driven from the area.
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