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Oxidative stress and alterations in DNA methylation have also been observed in diabetes, but no clear correlation between these events has been demonstrated until now.
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Recently, GilR was identified as the first bicovalently linked dehydrogenase, and for most pollen allergens, no catalytic function had been demonstrated until now.
However, no biochemical activity related to PIG-A has been demonstrated from archaeal sources until now.
Human mitochondria contain four members of the release factor family, two of which (ICT1 and C12ofr65) are lacking the stop-codon recognition domains and are thought to be codon-independent hydrolases, an activity which has been demonstrated only for ICT1 until now.
CCS is a technical possibility but it is hard to know what it will cost until it has been demonstrated.
Further, data that seem to indicate an absence of concentration should be treated with suspicion until it has been demonstrated that these data are not biased in some way.
There is a tension between the theoretical demand that specific types of crime be examined separately (at least until it has been demonstrated that they have the same pattern) and the pragmatic methods demands of examining a sufficiently large number of events that patterns can be detected.
This Hawthorne effect where people may modify their behaviour because of being observed [ 40] has been demonstrated to influence the time interval until cesarean section [ 41].
Third, self-administered tools are a novel experience for Iranians; as an alternative, training for and conducting interviews is costly and cannot be integrated into routine assessments until validity has been demonstrated in larger samples.
Since aberrant activation of the Wnt pathway has been demonstrated to contribute to leukemogenesis and until now, in contrast to solid tumors, no activating mutations in the genes of the Wnt pathway have been described in myeloid or lymphatic malignancies, we investigated epigenetic regulation of SFRP-1, -2, -4, and - 5 as negative regulators of Wnt signaling.
A third Leibnizean response to Mersenne's objection is that it is rational to presume the real possibility of the things we can conceive, at least until their impossibility has been demonstrated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com