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Their use has been debatable due to reports of worsening V/Q mismatch [ 114, 115], lack of long-term effectiveness through the development of tolerance [ 116, 117], and the high incidence of side effects including ankle oedema, headache, and facial flushing [ 117].
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What else it may have is debatable.
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(4 Treatment is debatable but HAART has been shown to prevent progression of renal disease.
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The degree to which they've been successful is debatable.
Just what has defined the genius of Pilobolus has always been debatable.
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