Such treatments have shown promising clinical results not only for tumours classically considered to be immunogenic such as melanoma and renal cell carcinoma, but also for common epithelial malignancies such as non-small cell lung cancer, which has been considered to be non-immunogenic and poorly responsive to immune-based therapies (Brahmer et al, 2012; Topalian et al, 2012).
Indeed, specific treatment guidelines are proposed for subjects with isolated hypertension, who should probably not have been considered as a population responsive to IPP/VPP, and whose inclusion may therefore have produced heterogeneity in the meta-analysis.
Thus, several approaches have been considered to determine if a candidate patient's disease-associated mutant form of α-Gal A is likely to be responsive to AT1001.
In the time course data, probes that displayed at least a 1.86 fold change (from the 0 hr, mock KSHV) in at least two time points and had greater than 75% present data were considered responsive.
All pixels that had magnitude values >60% of the peak level were considered responsive cortex and included for analysis, however cutoff levels between 10% and 90% yielded the same results.
Many responsiveness studies, however, have been published (and still are) in which an instrument was considered responsive just because the effect size was larger than 0.8.
"The ICBMs are considered responsive, the sea-launched are considered survivable, and the bombers... are flexible". I think Perry has the better argument.
Using this parameter, 18 samples would be considered responsive and 20 non-responsive.
Several studies characterising temperature-responsive resistance genes have been performed using different pre and post inoculation conditions, but the effect of temperature change has rarely been considered.
