Overcrowding has been a significant issue in London for many years.
In Ireland, the interest rate charged to the government has been a significant issue in elections scheduled for Feb. 25, with the opposition leader, Enda Kenny, promising to renegotiate the deal.
Doping has been a significant issue in tennis in the past in cases involving former Australian Open champion Petr Korda and also several Argentine players, including Mariano Puerta and Guillermo Coria.
The availability of affordable housing for those on low incomes has been a significant issue in the runup to the general election, especially in the capital, and several housing estate homes have been occupied by protesters.
While multidrug resistance (MDR) has been a significant issue in cancer chemotherapy, delivery resistance to various anti-cancer biotherapeutics, including genes, has not been widely recognized as a property of MDR.
"This for me has been a significant issue for a long time now, with Eriksson most culpable: there may have been a decent plan before the game started, but when have we last seen an England coach make a tactical difference during a game?" 4.44pm BST ITV are covering this match: Gordon Strachan, Gus Poyet and Andros Townsend are the pundits, with Matt Smith in the anchor's chair.
