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There has been a considerable cost.
The advent of HPV vaccine has been a major breakthrough.
"There has been a breakthrough in this meeting".
"There has been a breakthrough in this meeting," he said.
With the increasing development of arthroscopic technique, the application field of arthroscopy has been a breakthrough.
Detection of EBV DNA load in plasma has been a breakthrough in the diagnosis of NPC.
McIlroy's breakthrough has been a year in the making.
"And the past 12 months have been a massive breakthrough.
Three years on I thought there had been a breakthrough.
There have been a few breakthroughs.
There already have been a couple of breakthroughs.
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