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The paradigm that B cell response to self antigens (Ag) is promoted by antibodies (Ab) has become unsatisfactory.
Moreover, a classification system based on therapy has become unsatisfactory because of the increasing clinical trend toward early insulin use regardless of the presumed diabetes type (2).
Similar(56)
The Defence Management Board has become a chronically unsatisfactory instrument for decision-making.
It has become the recurring theme of Manchester City's difficult and largely unsatisfactory Champions League story, and the longer it goes on the harder the impression becomes of a team struggling to know what to do to put it right.
The move to create a new regulator has become becalmed as both press and government mull over the unsatisfactory and botched detail of the royal charter which is intended to enshrine its governance and independence.
As most patients with dyspepsia have functional disease, the treatment of which remains unsatisfactory at present [ 2], health-related quality of life (HRQOL) measurement has become an important clinical objective in the assessment of new therapies for this condition [ 3].
As most patients with dyspepsia have functional disease, the treatment of which remains unsatisfactory at present [ 4], health related quality of life (HRQoL) measurement has become an important clinical objective in the assessment of new therapies for this condition [ 5].
As the outcomes following modern tendon multistrand repair and controlled rehabilitation techniques are often unsatisfactory, alternative approaches, such as the application of growth factors and mesenchymal stem cells, have become increasingly attractive treatment options.
Changing the UI's, organization may frustrate users who have become familiar with the original design, whereas failing to make changes may force users to perform at an unsatisfactory level.
However, the detection results in[3, 4] become unsatisfactory when local manipulations with small tampered regions are conducted.
Although, chaos theory is a good application field in the design of evolutionary algorithms, many proposals become unsatisfactory.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com