Chaplin's Little Tramp is, of course, the ultimate cinematic depiction of natural nobility; in his old age, Chaplin's democratic sense had become refined enough not to deny that quality even to a hereditary ruler.
As the complexity of animal nervous systems has increased during evolution, developmental control of neuronal connectivity has become increasingly refined.
Over recent years the behavioural analysis of C. elegans has become increasingly refined with the introduction of automated computer systems [2].
Since its inception in the 1950s, bariatric surgery has become increasingly refined.
Once she broke up with Russell Brand and started seeing John Mayer, Katy started in on jeans, boots and sweaters (yes, regular sweaters); now that she's done with John, her style has become even more refined.
The present understanding of TB immunology has become greater and more refined since the identification of Mycobacterium tuberculosis (MTB) as an etiologic agent of disease and the recognition of new signaling pathways modulating infection.
Hydrotreating has become a critical refining process as fuel sulfur specifications are tightened around the world.
With significant advancements in genetics, proteomics, cellular and molecular biology and biomaterials engineering, the nanomedicine strategies have become progressively refined regarding the modulation of surface and bulk chemistry of the nanovehicles, control of drug release kinetics, manipulation of nanoconstruct geometry and integration of multiple functionalities on single nanoplatforms.
The technologies used to generate new therapeutic antibodies have become highly refined.
A process of constant comparison was carried out throughout the collection, selection, coding and analysis of data until saturation was judged to be reached and concepts had become satisfactorily refined.
