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The understanding of the overall role exerted by GPER in this neoplasia has become rather complex, considering the strong evidence of its ability to mediate the estrogen stimulation of main components of the tumor microenvironment, such as CAFs (De Francesco et al., 2014; Madeo and Maggiolini, 2010; Pupo et al., 2013, 2014; Vivacqua et al., 2015).
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It had become rather more than a mere distraction.
Research has become very molecular and, unfortunately, traditional anatomical studies have become rather passé.
Her voice had become rather dreamy.
Thus, the arthroplasty history of patients may eventually become rather complex.
The model behavior easily becomes rather complex and puzzling if we study more than one species.
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