Sentence examples for has become difficult with from inspiring English sources

Despite the availability of multiple conventional antibiotics as well as the new generation broad spectrum antibiotics with improved efficacy, the management of pneumococcal infections has become difficult with the rapid development of antimicrobial resistance in this organism.

In the world of business-to-business Internet commerce, it has become difficult to keep up with the rapid-fire creation of so-called e-marketplaces -- the darlings du jour of the investment community.

It is interesting to note that students feel confident in taking Pap smears, as it has become difficult to provide students with opportunities to perform vaginal and speculum examinations in clinics.

You are too tired to see family and friends and conversing with visitors has become difficult.

Permission Marketing With thousands of colleges and universities bombarding high school juniors and seniors with mail, it has become difficult and expensive for messages to be heard.

To Lanier, a computer scientist and author, the common thread is that the Internet in general — and social networking in particular — has become difficult for the ordinary person to use with any security.

Recently, LTRAs have been proposed for use in elderly individuals with asthma which has become difficult to treat because of steroid resistance.

What sets them apart has become difficult to define.

With the expanding phenotypical spectrum of atypical parkinsonian conditions, the early identification of patients has become difficult.

Reaction in Boston was mixed: some fans were embittered at the loss of Ruth; others conceded that the slugger had become difficult to deal with.

It had become difficult to fit in with other people's plans.