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Moreover, its ability to acquire and/or maintain antibiotic resistance genes has become a considerable problem and an obstacle to successful therapeutic treatment [ 4, 5].
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Child health disparities have become a considerable problem in global public health.
Therefore, the prevention and treatment of chronic diabetes complications have become a considerable medical problem attracting worldwide attention.
By the mid-19th century the practice of quarantine had become a considerable nuisance.
This has become a huge problem".
And so the "Trust problem" has become a trust problem.
Now this has become a social problem.
Now the white vote has become a Republican problem.
Childhood obesity has become a significant problem in many countries.
has become a prominent problem.
Global warming has become a serious problem.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com