However, as outlined in our recent review (Mur et al. 2011), nearly all the approaches currently employed have associated problems.
Although ecologic studies can be useful for detecting associations between exposure distributions and disease occurrence, the use of aggregated data does have associated problems.
Women had overwhelmingly negative concerns; an HPV diagnosis was daunting, had associated problems of disclosure of a sexually transmitted infection (STI), impacted on relationships and provoked fear of stigmatisation.
This would negate the need for sourcing autologous cells, for example, from adipose tissue or bone marrow, which have associated problems of donor site morbidity and limited cell number.
Nowadays, the market is full of synthetically manufactured neutralizing agents having associated problems like toxicity and/or mutation induction, resulting in attention of many researchers to look for natural antioxidant [ 3].
These measures, including microvessel density, have associated problems [ 46] and none provides a reliable measure of blood flow, which is extremely variable because of shunting, stasis and even reverse flow occurring through the abnormal tumour vasculature [ 47].
I have a degenerative spinal condition which has associated neurological problems that mean I'm in constant pain and that over time the discs in my spine will disintegrate.
Surgical pancreatectomy is a second option, but its execution is difficult and it has associated morbidity problems.
"Basically the doctor stated that with Down's syndrome at his age, people's reserve is limited, that they age faster than the rest of the population and have associated heart problems".
Some research suggests that, like pseudohalitosis patients, genuine halitosis patients may also have associated psychological problems, such as social anxiety disorder [ 7, 12], that may be overlooked.
