HIF1α protein has also been shown to be stabilized under normoxic conditions by growth factor stimulation or due to mutations in the VHL protein [ 20].
It is of note that PCAF, another acetyltransferase, has also been reported to stabilize E2F1 [22] and β-Catenin [21] through acetylation.
DM has also been shown to stabilize unbound MHCII from the irreversible loss of the peptide binding site or rescue misfolded MHCII from denaturation and aggregation [11], [12].
In support of this mechanism, the T-plastin isoform has also been reported to stabilize actin filaments and modulate Arp2/3-mediated actin assembly in an in vitro reconstitution assay [46].
In addition to catalyzing peptide binding and release, the peptide exchange factor HLA-DM has also been shown to stabilize the peptide-receptive form of MHC II and to prevent conversion to the inactive form [14], [15], [47], [48].
At last, polyuridylation has also been reported to stabilize RNAs, rather than destabilize them.
PAR-1 has also been shown to stabilize Oskar protein through direct phosphorylation [33].
A putative electrostatic interaction between Pol II and histone octamer has also been predicted to stabilize the Ø-loop intermediate by structural modeling[ 3].
Since mDia has also been shown to stabilize MTs (Palazzo et al., 2001), we analyzed the subcellular localization of mDia1 in ILK-K5 cells, and found its cortical localization and overall proteins levels to be reduced compared with control cells.
The 7-methylguanosine cap is required for the translation of the majority of mRNAs, and it has also been reported to stabilize mRNA against attack by exonucleases and to promote transcription, splicing, polyadenylation and nuclear export of mRNA.
