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XPC rs2229090 has also been imputed from Hapmap phase 2 variants in the Nijmegen and Icelandic bladder cancer study populations (B.Kiemeney, personal communication), with no association found with bladder cancer risk (combined OR = 0.99, 95% CI = 0.89 1.09, P = 0.80) despite this variant having the highest predicted |ΔΔGtot| of 113.27 for differential miRNA binding.
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For GWAS, it has also been suggested to include the uncertainty of imputed genotypes to improve power [ 28- 31].
Informal graphical techniques, such as plotting the imputed and observed variables, have also been recommended [ 7, 8].
Sporadically missing genotypes can also be imputed in order to improve the genotype call rate [ 8].
If studies have already been imputed up to dense reference panels, credible set variants can also be investigated for functional annotation.
The reason has been imputed to probable interactions between DPE, PA6 and clay.
Missing values (<15%) have been imputed in this study too.
Somewhat paradoxically, p-values were consistently smaller when 50% of the data had been imputed, compared to when a larger proportion of the data (80%) had been imputed.
QIDS data used in this plot have been imputed using last value carried forward.
Second, once data have been imputed, the imputed data can be used to conduct a variety of analyses.
Less than 5%% of the values of all data were missing and have been imputed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com