Cell suspension cultures of plants have also been efficiently employed for the biotransformation of organic compounds, e.g., steroids [3], terpenes [4, 5], alkaloids [6] and flavonoids [7].
TALEs have also been efficiently fused to the TET family of active DNA demethylases and drive gene expression in targeted sequences by actively removing DNA methylation [ 77, 78].
The far zone transformation has also been implemented efficiently, using specialized MPL functions to evaluate the far zone scattering results.
This peptide can be presented by human HLA-A2402 (Okugawa et al, 2000), but it has also been shown to be efficiently presented as an immunodominant CTL epitope by murine H-2Kd in BALB/c mice (Nagata et al, 1997).
Recently, HRMAS has also been used to efficiently trace the geographical origin of 60 fermented and dried cocoa beans obtained from major growing areas in Africa, Central/South America, Asia/Oceania [58].
51 Sitagliptin has also been shown to efficiently improve glycemic control when used in monotherapy in a study comprising 530 Asian patients.
PET imaging with C-PIB has also been used to efficiently differentiate patients with mild cognitive impairment (MCI) who have converted to AD from nonconverters [ 8], and to estimate the decreased amyloid load in patients treated with bapineuzumab [ 9].
Succinylated gelatin (Gelofusine, Gelo), a plasma expander that consists of a mixture of collagen-derived peptides, has also been shown to efficiently reduce the renal reabsorption of various radiolabelled peptides in animals, and of In-octreotide in humans [ 1, 21– 23].
Recently, Cdc6-E224G halsolso been shown to efficiently load MCM in vitro using only purified proteins (Coster et al., 2014; Kang et al., 2014) and this allele is also defective in ATP hydrolysis (Randell et al., 2006; Speck and Stillman, 2007).
