Your English writing platform
Discover LudwigSuggestions(1)
Exact(3)
The discovery of a TID domain at the far C-terminus of nvp63 suggests the existence of a regulatory mechanism for nvp63 protein activity that has also been conserved through evolution.
Notably, this glutamine has also been conserved in Fam20A throughout evolution.
The fact that the detailed structure of this domain (at the level of individual amino acids) has been conserved over evolution is often taken as an indication that its mechanism has also been conserved.
Similar(57)
Certainly, the identification of Polo targets during cytokinesis in both flies and mammals will be crucial if we are to understand whether the downstream events regulated by this important family of mitotic kinases have also been conserved.
Many of the core mechanisms used by amoebae to sense, ingest and kill bacteria have also been conserved in specialized phagocytic cells in mammalian organisms.
The regulatory mechanisms controlling transcription initiation are the most thoroughly described in free-living bacteria [ 18] and genome organisation suggests that they have also been conserved in Buchnera[ 26].
Expression of human K protein rescues these fly phenotypes, suggesting that like the structure, K protein function has also been evolutionarily conserved.
Interestingly, dmrt1 has also been shown to be conserved on the Z chromosome in the majority of bird species (Stiglec et al. 2007) including in the ancient ratite emu species (Shetty et al. 2002), suggesting a conservation of this gene as the master sex-determining gene in all bird species.
However, for cases such as the hammerhead, hairpin, and GlmS ribozymes for which very high concentrations of monovalent cations can support varying levels of ribozyme activity, it has also been found that conserved nucleobases play intimate roles in the reaction.
Our automated approach, Function Discovery V1.0 has also been effective in finding conserved genes clustered near our target genes and for ten randomly chosen TRs that have known effectors and functions (Table 1).
It has also been suggested that some disordered regions are conserved over long evolutionary distances even when the specific amino acids are not (Chen et al. 2006; Daughdrill et al. 2007; Toth-Petroczy et al. 2008) and that there is a subset of disordered regions that are conserved at the amino acid level (Bellay et al. 2011; Colak et al. 2013).
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com