This compound has additional activity against EGFR and fms-like tyrosine kinase 4 (VEGFR3) (Ciardiello et al, 2003).
When choosing between the fluoroquinolones, clinicians should take into account the patterns of pathogens and resistance in their patient population, and remember that, compared with ciprofloxacin, levofloxacin has additional activity against Gram-positive organisms but less anti-pseudomonal activity (MacGowan et al, 1999; Montanari et al, 1999).
Once considered to function exclusively as sequence-specific DNA-binding motifs, ZnFs are now known to have additional activities such as the recognition of RNA and other proteins.
Moreover, some members of the plant defensins family were found to have additional activities in vitro.
ZNF proteins are now known to have additional activities such as the recognition of RNA and other proteins [ 4].
Both RasGRFs were first discovered for their ability to exchange the nucleotide bound to Ras proteins [ 6, 7] but these multidomain proteins can have additional activities.
Moreover, several enzymes of TAG synthesis and degradation have additional activities, suggesting that they also may play a role in phospholipid acyl-chain remodeling (Rajakumari et al. 2008; Kohlwein 2010b; Rajakumari and Daum 2010a, b).
HDACs have additional activities that are not directed at histones: many HDACs are partially found in the cytoplasm, and some have been shown to act on non-histone substrates, such as the cytoskeletal protein, tubulin, and the transcription factors p53 and YY1 [ 5- 7].
In this pathway, the only functional gene present in BCpu is the one coding for sulphite reductase (NADPH) flavoprotein subunit alpha CysJ, a flavin reductase (EC 1.5.1.30), which is described to have additional activities such as electron relay (Siegel and Davis 1974) and has, therefore, been retained.
The barrier has additional antimicrobial activities: synthesizing high levels of nitric oxide synthase, producing microvillus-associated glycosaminoglycans, and secreting antiviral interferons [ 36].
