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Though Banks suggests that PACAP has actions in the CNS and provides evidence in support [95], the available data strongly indicate that PACAP does not pass the wall of cerebral arteries, as studied in isolated perfused MCAs [96], which agrees with the view that the peptide is a large molecule that does not pass the blood-brain barrier (BBB) [96, 97].
Importantly, B7-DC XAb also activates human DC [3] and has actions in several experimental models of cancer in which results from the use of TLR ligands or TNF family members have been less impressive [4], [5].
Together, those studies indicate that HSS has actions in two important aspects of septic shock: hemodynamics and immunomodula-tion.
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A comprehensive body of evidence now exists that CSFs have actions in cardiovascular diseases, among which atherosclerosis (Table 1 ).
These data indicate that type I IFNs have actions in the CNS, but that these, like sickness behaviour in a general sense, are largely adaptive.
We have action in Albany.
But if you have action in many countries, when one country is suffering problems you can enjoy prosperity in another part of the world.
You have to take action in adversity.
NR2F2 has been shown to have many actions in reproductive tissues.
Vitamin D has various actions in skeletal muscle.
Although estrogen has beneficial actions in brain, recent clinical trials demonstrated adverse neural effects of hormone therapy in postmenopausal women.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com