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αSNAP has a well characterized function in SNARE complex disassembly.
PhoB has a well characterized DNA binding domain whose affinity for DNA is strongly enhanced by phosphorylation [17], [18], [19].
For example, HSP70h from Closterovirus which is involved in virus translocation from cell to cell, has a well characterized ATPase function [48].
The metalloprotease ADAM17 has a well characterized "sheddase" activity, in which it releases membrane bound proteins from the cell surface, often initiating their signaling ability [4], [5], [6], [7].
Unlike many other Apicomplexa, which are experimentally intractable, T. gondii is easily cultured in vitro, has well established experimental protocols for genetic manipulation, and has a well characterized mouse model [5].
For example, the SFRS7 gene encodes the SR splicing regulatory protein 9G8, which has a well characterized AS-NMD event involving a "poison" cassette exon [ 55].
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We specifically selected this region to have a well characterized reference sequence to compare our experimental results to.
However, some genes such as Pgc1α have a well characterized induction pathway involving β-AR signaling independent of circadian regulation [ 69].
Even among persons with cystic fibrosis, who have a well characterized genetic predisposition to pulmonary NTM disease, sex differences exist (23, 27 ).
It should be noted that bisphosphonates are a well established treatment option with a long history of clinical use in this patient population and have a well characterized and manageable safety profile.
p21 (WAF1/Cis1) is the only member of the CIP/KIP family which has a well-characterized PCNA-binding domain.
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