Bringing all the results together has been a technical challenge, she says, but the real issue is that "nobody has taken the time to think about what insights they are trying to drive".
N-linked glycosylation has been detected only at very low levels in P. falciparum [17], and ensuring appropriate glycosylation in heterologously-expressed P. falciparum proteins has been a technical challenge in the development of malaria vaccines [18], [19].
Although the use of whole blood sample is preferable for device performance evaluation, fractioning various target components from it has been a technical challenge due to its massive number and wide diversity of cell type.
This has been a technical challenge as some off-shelf devices fail to provide constant output rate based on performance testing [ 16]; second, the aerosol flow rate must equal or exceed the peak inspiratory flow in order to avoid any potential aerosol dilution during the inspiratory phase of the breathing cycle [ 47].
Whilst the maintenance of very long tandem repeat mutations in mouse lines has been a technical challenge (particularly for fragile X syndrome), this can no doubt be overcome so that such tandem repeat disorders are modeled with optimal genetic construct validity.
However, IPV-containing hexavalent vaccines have been a technical challenge for vaccine manufacturers since work began in the early 1990s to combine pediatric vaccines.
Yet the morphological changes in RP diseased eyes that leads to the loss of the IS/OS boundary and thinning of the ONL have remained a technical challenge for the automated segmentation of the OCT images.
Staging grandiose scenes such as the temple's fall and the opera's mass dances has long provided a technical challenge for directors.
Multiple modifications have been attempted to facilitate construction of the anastomoses, which has been recognized as a technical challenge and requires a substantial learning curve to achieve acceptable reproducibility [ 27].
BamBrogan says that they'll look to source the best available engineers because they have a significant technical challenge, combined with a desire to actually change the world in very practical and impactful ways.
