Sentence examples for has a sizeable impact from inspiring English sources

Reducing the applicable price of sumatriptan in each country by 50% has a sizeable impact on the cost and cost-effectiveness profile for this drug (reducing baseline cost-effectiveness ratios [CERs] by 30-40%), but not enough to bring it close to simple analgesics.

So if just a small proportion of Mr. Gephardt's potential labor support materializes, it could have a sizeable impact.

If there's one thing she can't stand, it's anyone who demonises women, an outlook that has had a sizeable impact on her own career.

The CBO's projections suggest that a few years of modest surpluses would have a sizeable impact on the national debt.

Chen et al. [ 38] also found that truncation can only have a sizeable impact when it is so severe that it affects the left side of the patient.

Community-based distribution and other innovative distribution mechanisms for an LAI would have a sizeable impact on enhancing potential users' access to the method.

Few would deny that this new configuration has had a sizeable impact on public and political life in the past 30 years.

In any case, these processes seem to have a sizeable impact on the resolution of short internal branches of the mammalian tree and phylogenetic reconstruction in general.

To establish appropriate Markov states it is thus necessary to estimate which variables have a sizeable impact on the costs associated with being in a state together with the transition probabilities determining movements between states.

In contrast, amphotericin B formulations and echinocandins are only available in parenteral formulation and, thus, their administration in a prophylactic manner would be expected to have a sizeable impact on quality of life.

This suggests that idiosyncratic effects such as the bargaining skills of the individuals at the negotiating table rather than structural conditions such as the outside options might have a sizeable impact on the market outcomes.