Sentence examples for has a significant functional from inspiring English sources
Genu recurvatum occurs in 4 16% after hamstring lengthening but seldom has a significant functional effect as it does not usually exceed 5 10° and also improves with time [9, 11, 16, 24].
Taken together, these findings indicate that Mcl-1 downregulation has a significant functional role in BITC-mediated lethality.
Moreover, evidence is presented suggesting that disrupting Rho/ROCK1/ezrin pathway has a significant functional role in UA-related lethality.
Furthermore, we demonstrated that PIP has a significant functional role in maintaining cell invasion and viability of molecular apocrine cells because of a positive regulatory effect on the Integrin-ERK and Integrin-Akt signaling pathways.
Importantly, our studies reveal that IRS-1 has a significant functional role in erbB3 signalling in MCF-7 and T47D cells, as erbB3 knockdown using siRNA potently inhibited basal and HRGβ1-induced IRS-1, Akt and ERK1/2 phosphorylation, whilst IRS-1 siRNA similarly reduced HRGβ1-induced Akt and, to a modest degree, ERK1/2 activity in these cells.
After correction for multiple hypothesis testing, InVEx identified only PTCH1 (Patched 1) as having a significant functional mutation burden.
Neuropsychological data revealed no significant executive dysfunction in both migraine groups compared to HC. RS-fMRI showed that both MwA and MwoA patients, compared to HC, had a significant functional connectivity decrease within the right FPN and specifically in the middle frontal gyrus and the dorsal anterior cingulate cortex.
This suggests that interventions enhancing memory could have a significant functional impact, but that the impact may be different in patients with different neuropsychiatric disorders.
With the full length LfcinB however, the native disulfide bond that connects the ends of the peptide does not have a significant functional role, as seen by the similar activities between the oxidized and reduced forms of the peptide.
mTert as well as being a marker, may have a significant functional role as well.
On the basis of these structural features, we hypothesized that CP could have a significant functional impact on the enzyme.
