It was also observed that CST supported on PTFE or PE fibrils had a significant affinity for both cesium and strontium.
In regards to the pharmacological profile, olanzapine is known to have a significant affinity for muscarinic receptors and to induce relatively more anticholinergic adverse effects than the other three antipsychotics [ 65, 66].
One of the best tumour localisers reported in the literature, TPPS4, hardly binds to LDL, while Hp and Pp, which are commonly considered inefficient tumour localisers, do have a significant affinity for LDL.
LBTs are short and genetically encodable polypeptide sequences derived from Ca2+ binding loops of various proteins such as troponin C. Since lanthanide ions have similar ionic and structural characteristics as Ca2+ ions, they have a significant binding affinity for Ca2+ binding loops8.
Biological evaluation revealed that alterations to the aromatic ring had a significant effect on affinity for gp120 and the degree of CD4 mimicry.
Fenoldopam has no significant affinity for dopamine2 receptors.
Cbp20 and Cbp80 bind to 7mG synergistically and neither subunit alone has significant affinity for the structure [ 29, 30, 36].
These components as well as antioxidants (rosemary oil components), traditional cold medicines (ginger, pepper) and common natural essential oil products have shown significant affinity for H1N1 neuraminidase (Table 1).
The divalent Mg ion has an enhanced ability compared to other cations to form bidentate clamps with RNA, because the oxyanions of RNA phosphates have significant affinity for Mg2+ (Fig. 3) (Petrov et al., 2011).
By applying a recently developed sequence prediction algorithm and a novel ensemble averaging calculation, we generate a diverse collection of peptide sequences that are predicted to have significant affinity for the protein.
Finally, analyses of heterotropic effector binding isotherms suggest that active site ligands may have significant affinity for the regulatory sites, which gives rise to underestimates for the allosteric equilibrium constants determined from substrate analog binding isotherms.
