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Clinical observations suggest that PHN has a severe impact on several aspects of quality of life and on functional status.
My work on biomedical research in developing countries has shown me that lack of access to current publications has a severe impact.
According to Boubacar Barry, head of the education programme at the association for the promotion of livestock herding in the Sahel and the Savannah (Apess), putting children in formal school has a severe impact on a pastoral family's livelihood.
Gatwick is the busiest single-runway airport in the world, so any closure has a severe impact: easyJet and British Airways cancelled dozens of flights, and many more were heavily delayed.
We achieved this progress in spite of the dollar's 31percentt decline against sterling in that time, which has a severe impact on Pearson since we generate about two-thirds of our sales in the United States but report in sterling.
Patients with insomnia tend to think that one night of poor sleep leads to health problems or has a severe impact on their mood the next day, a mental pressure-cooker that leaves them fretting that every second they are awake in the middle of the night is another grain of salt in the wound.
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It seems enough to conclude that tuition fees have had a severe impact on university anticipation.
Servante's illness has had a severe impact on his relationships with the opposite sex.
"A loss of $75 million will have a severe impact," Ms. Schaps said.
"Loss of intellectual property can have a severe impact on an organisation".
But he added, "It could have a severe impact on the designs of the future".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com