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The small GTPase Ras-related protein 1 (Rap1) belongs to the Ras superfamily and has a pivotal function in lymphocyte integrin activation [9] [11].
c-Myc has a pivotal function in the development of breast cancer.
Furthermore, BubR1 monitors kinetochore-microtubule attachments and has a pivotal function in checkpoint signaling (Abrieu et al, 2000; Lampson and Kapoor, 2005; Elowe et al, 2007).
To test whether C/EBPalpha has a pivotal function in shifting osteoblast and adipocyte differentiation balance during Dex treatment, we used shRNA to knockdown C/EBPalpha in Dex-induced osteoporotic BMSCs.
This study combines genetics and functional data from C. elegans with a new knockout mouse model to demonstrate that the DOHH-mediated step of hypusine modification has a pivotal function in murine and nematode development, in cell proliferation, malignant transformation and translation.
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Both gene products are known to have a pivotal function in pain mechanisms, thus making these associations particularly stimulating.
In addition to the originally identified role in defence signalling, WRKY TFs have a pivotal function in seed germination, flower development, senescence and the abiotic stress response (Tripathi et al. 2014).
The characteristic expression of Unc-51 in the newly differentiated MB axons suggested that Unc-51 might have a pivotal function in the integrity of the MB core.
Endoglin has furthermore been described to have a pivotal function in vascular development and disease [ 28].
Adhesion molecules have a pivotal function in allowing interaction of muscle cells with immune cells.
After an analysis of the array data we found some candidate genes that might have a pivotal function in AIA.
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