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How their size is determined and whether it has a functional relevance are at present unknown.
The conservation index of this position is 100% indicating that it has a functional relevance and that probably is not neutral.
An interesting observation is the high correlation between striated muscles and adipose tissue, which may partly be explained by presence of adipocytes in the heart and skeletal muscle samples, but it possibly also has a functional relevance related to metabolic activities.
In addition, TMEM27 has a functional relevance in beta cell proliferation and insulin secretion [ 19, 32], and, although its levels were found to be decreased in islets derived from diabetic donors compared with healthy controls, it was still present in these patients [ 33, 34].
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Several studies have now shown that the expression pattern of noncoding RNAs can be altered in several human diseases such as cancers and heart disease [14], [15] suggesting that noncoding RNAs may have a functional relevance to human disease and that they may be considered as potential drug targets [11], [16].
Moreover, it has been assumed that overlapping transcripts should have a functional relevance for regulation of gene expression [ 27- 31].
Specific physical and biomass attributes that have a functional relevance would figure prominently in an old-growth forest index that might be used to evaluate or establish priorities for conservation and management.
This may indicate that both 5' and 3' arms of the pre-miRNA can be expressed in specific tissues/cells and that they may have a functional relevance.
It may, instead, have a functional relevance for RNA processing or stability even while not being involved in any of the predicted pre-miR168 secondary structures.
This method is known to give values of modularity comparable to what is found using e.g. simulated annealing, and has been observed to give modules that have a functional relevance.
Although p33ING1 and p53 have a functional relevance in certain biological process, there are studies showing p33ING1 could exert a p53-independent function in apoptosis or cell growth inhibition.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com