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E54 in Mtb BfrB has a flipped orientation that is stabilized by formation of a salt bridge with R180 (unique to mycobacterium species, Figure 3) suggesting an altered C-site in Mtb BfrB.
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In the first mode, the isopropenyl side chain of carvone points toward F296 and Y375, which Stewart refers to as the "normal" mode because it produces the natural (R/ S -diastereomer 4. The S -diastereomer the carvone in a "flipped" orientation, with its side chain directed toward position 116.
If you don't feel like craning your neck, Eater DC has a flipped-up version.
In contrast, a flipped orientation was observed for compound 13.
That both a Tyr and Trp side chain at position 78 appear to be too large to allow binding of 1 in a "flipped" orientation may explain why an alternative binding mode is not observed for this alkene.
Some work in the show has a determined horizontal orientation.
The school has a Catholic religious orientation.
Evangelical Christianity has a strong dominance orientation.
My organization has a strong future orientation.
University education has an academic orientation.
KT has an inherently democratising orientation.
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