The Drosophila STE24 function has a demonstrated role in the male germline, and it appears to have undergone serial duplications in the genome.
Decreased CTNNB1 expression could also be a consequence of enhanced NOTCH1 expression, which has a demonstrated tumor suppressive function in mouse skin.
Another alphaherpesvirus, bovine herpesvirus 1 (BHV-1), expresses a latency-related (LR) protein, which has a demonstrated anti-apoptosis function (Ciacci-Zanella et al., 1999; Henderson et al., 2004) and expression of this protein from HSV-1 deleted for LAT expression rescued the reactivation phenotype of this virus in rabbits and mice (Perng et al., 2002).
First, the RNA encodes no protein and has no demonstrated function.
In this core set, only a handful has demonstrated functions (e.g., TIR1/ABF1-5, COI1, EBF1/2, FBL17, SLY1, and ZTL (Table S3)).
It is therefore unsurprising that miRNAs have demonstrated functions in a diverse array of processes, including development, cell behaviour, stress responses and survival (Bushati and Cohen, 2007).
lncRNAs have a range of demonstrated functions, including chromatin remodeling [ 10], alternative splicing [ 11] and mRNA degradation [ 12], and their dysregulation has been linked to many disorders, including cancer [ 13- 15].
However, this protein also has a defensive function, having been demonstrated that fibrinogen concentration increases during acute-phase reactions [ 55, 56].
A truncated AtPDIL2-1 mutant has been demonstrated to function as a gain-of-function mutant in sporophytic tissues and to affect ovule structure and impede embryo sac development, thereby disrupting pollen tube guidance.
However, in contrast to the animal model, neither for rheumatoid factor nor for any of the other autoantibodies in RA has an effector function been demonstrated that could be linked to joint inflammation.
