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"There was not a harsh bone in that girl's body.
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Tranquility Bay was known for making kids kneel on concrete for days and using "restraint" so harsh that it broke bones.
Injuries such as broken bones of harsh bruises can occur.
In that game, a harsh tackle from Nigel De Jong broke a bone in his leg, which limited his ability to be fully fit for the World Cup.
However, due to a complex mechanism profile, glucocorticoids also cause harsh side effects such as brittle bones, muscle wasting, stunted growth, adrenal suppression and weight gain.
Aggressive interventions including surgical removal of the bone and followup chemotherapy can have harsh side effects and are only partially effective, with 50% of these patients dying of this disease.
The sound of the ball colliding with the bones in Jeter's hands was harsh and had to concern the Yankees.
He played Dredd with a raspy and harsh vocal tone akin to "a saw cutting through bone", which he found difficult to sustain.
IVD repair using bone marrow derived mesenchymal stem cells (MSCs) is an attractive approach and the harsh microenvironment of the IVD suggests pre-differentiation is a necessary first step.
As the CAR T cells are likely to face a harsh microenvironment in the tumors and, in particular, large amounts of TGF-β, which are typical for prostate cancer bone metastases, dominant-negative inhibitory receptors could be utilized.
Cut marks on bones and reports from local Inuit confirmed some of the crew resorted to cannibalism in the harsh and desperate conditions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com