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The secondary amine was obtained under harsh base conditions using NaOH, whereby the substituted benzyl group was introduced in a microwave-assisted aqueous N-alkylation.[ 16] Surprisingly, the employment of four equivalents of Li base was not sufficient for the lithiation of pyridine 4 a (59 % yield); increasing amounts of the base raised the yield of chloride 4 b fourfold to 78%%.
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Armed with knives and iron bars, about 50 rebels overpowered police guards, demanding that authorities recognize them as prisoners of war and demolish a harsh navy base jail near Lima where rebel leaders are held.
One example is Saudi Arabia, where the ruling family imposes harsh penalties based on sharia law because it rules in tandem with the puritanical Wahhabi clerics.
She also pointed out that the sentence seemed especially harsh and based on the flimsiest of evidence — but that could hardly be called unusual.
In the slippery-slope battle, some students counterargued with admonitions against ignoring special circumstances and making disproportionately harsh judgments based on unproven hypotheses.
His Teeth, performed by the ex-offenders of the Only Connect company, fills a former Baptist chapel with harsh stories, based on real-life accounts, of illegal immigration and 21st-century slavery, machetes, prostitution, heroin, beheadings.
It used to control much of southern and central Somalia, meting out harsh punishments based on Islamic law, such as stoning for adulterers and amputating the hands of thieves.
In closing statements, Shkreli's lawyer, Ben Brafman, characterized his client as someone lacking certain social graces but begged Judge Matsumoto not to hand down a harsh sentence based on that.
Since its implementation, NCLB has been criticized for creating a culture of "teaching to the test" and for meting out harsh consequences based on blunt metrics that rely on those same tests.
A soap containing tea tree oil is antiseptic naturally, unlike other harsh chemical based soaps.
From the nineteen-sixties on, Rivers had been the purveyor of a harsh Realpolitik, one based on her experience: looks mattered.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com