As a proof of concept to achieve the second aim, we harnessed this system to explore the possible specific toxic effects of Aβ25-35 Aβ25-35n endonhelial cells, astrocytes and pericytes, while maintained cell-cell communication without formation of a true brainendothelial
"When harnessed, this system has the potential to write arbitrary information into the genome.
We have harnessed this system to explore the roles of dynamically expressed nuclear hormone receptors in molting, and to analyze meiosis-specific roles for proteins required for germ line proliferation.
Recognizing the potential of harnessing this system for precise genome engineering in other organisms, Jinek and colleagues (Jinek et al. 2012) identified a minimal two-component system required for the site-specific cleavage of DNA Cas9 and a chimeric RNA (chiRNA) comprising the crRNA and tracrRNA from Streptococcus pyogenes.
Collectively, these observations point to DM per se as the adverse factor and suggest that the suppression of the NRG-1β/ErbB pathway induced by STZ-diabetes precludes harnessing this system as a compensatory mechanism to help in recovery of myocardial function after superimposition of cardiac injury involving MI.
Yet technology executives insist they must harness the system lest they be crushed by it.
This year commercial products based on Watson were unveiled for clinical use, harnessing the system's ability to crunch through swaths of medical information and make decisions.
In January, four research teams reported harnessing the system, called CRISPR, to target the destruction of specific genes in human cells.
This avenue of research represents a vast area for new biological discovery and we seek to understand the function and mechanism of the pathways elicited, to identify pathogen strategies for averting these effects, and to harness this powerful anti-infection system for therapeutic purposes.
The genius of this system was in harnessing social capital for the maintenance of the system so that there was accountability and responsibility built into it.
This system has been harnessed for genome engineering in a broad range of organisms [ 60, 74].
