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The Danish Lung Cancer Screening Trial, a randomised controlled trial, ran from 2004 to 2010 with the purpose of investigating the benefits and harms of lung cancer screening.
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> Recently, de K oning et al. [ 39] published a study estimating the harms and benefits of lung cancer screening for efficient lung cancer screening policies.
The former two studies predict lung cancer detection, while the latter predicts death by lung cancer (Table 3).> Recently, de Koning et al. [ 39] published a study estimating the harms and benefits of lung cancer screening for efficient lung cancer screening policies.
The possible harm of increased lung edema was investigated by Martin and colleagues [ 23].
Over the past three decades, an intensive scientific debate on the effectiveness and possible harm of extracorporeal lung assist systems was stimulated by clinical investigations studying ECMO or extracorporeal carbon dioxide removal in rescue situations (life-threatening hypoxaemia/hypercapnia) of patients with ARDS [ 14- 17].
In addition, we discovered that the bactericidal effect of artocarpin can reduce the viability of pneumococci by a factor of >1000, without obvious harm to lung epithelial cells.
As surgery is becoming more extensive, the inescapable harm done as a consequence of lung resection is increasing.
Despite this considerable harm, we know relatively little about the natural history of lung disease and respiratory impairment in adults, especially after smoking cessation.
Consequently, the potential for benefit or harm may depend critically on the degree of lung recruitment in response to increasing mean airway pressure.
Although hypercapnia might have beneficial effects on oxygen delivery and attenuation of inflammation [ 12], it also harms injured lung through immunosuppression and impaired pulmonary epithelial repair [ 13, 14].
In the absence of lung recruitability, however, PEEP may solely increase stress/strain with no benefit or even harm to the patient.
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