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Because there were a number of important in vitro micronucleus validation studies in progress, it was not possible to design a definitive, internationally harmonized protocol at that time.
In further iterations, participants were asked to perform the assay again, using the harmonized protocol.
The results presented here represent the first attempt by an integrated consortium of independent labs to determine whether the effects of well-characterized ENMs on pulmonary responses in mice and rats could be reliably reproduced by multiple investigators using a harmonized protocol.
Harmonized protocol.
The method used conformed to the guidelines outlined in the EADC-ADNI Harmonized Protocol for Manual Hippocampal Segmentation User Manual (HarP); however, in a deviation from the protocol, segmentation was initially performed in the sagittal plane (rather than the coronal plane) before further editing in the coronal and axial planes to check and refine the segmentation [10, 11].
The revised Harmonized Protocol (5) describes several ways in which the SDPA can be obtained.
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Presetting DRO as a reference allows a variety of institutions to easily join the harmonization projects without any revisions of previously harmonized protocols in enrolled institutions, whereas the two-step approach seems complex when many scanners need to be harmonized. .
Presetting DRO as a reference allows a variety of institutions to easily join the harmonization projects without any revisions of previously harmonized protocols in enrolled institutions, whereas the two-step approach seems complex when many scanners need to be harmonized.
Urinary concentrations of pyrethroid insecticide metabolite, 3-phenoxybenzoic acid (3-PBA), were measured by LC/MS/MS and semen parameters were measured by following internationally harmonized protocols.
Although harmonized protocols guarantee the comparability of results, PIAAC remains a collection of country surveys, each of which has been constructed independently.
To help ensure validity and transferability of results, researchers developed harmonized protocols and quality controls for chemical and data analyses.
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