In this paper we analysed multiple factors that are of potential significance for ELISpot performance and identified those that will need to be harmonized between laboratories if comparisons between immune responses are to be made.
It has been mentioned that a lack of harmonized data may make comparisons difficult.
14, 20– 23 A recent report recommended the use of standardized evaluation criteria for G6PD tests to better harmonize the performance comparison studies of different G6PD diagnostic tests. 2 This approach includes using a quantitative test to measure activity levels and establish a normal G6PD activity reference value for a study population.
Waist circumference is a required component of the IDF definition, which may explain its lesser discrimination of risk in comparison with the harmonized version.
Fourteen-day period prevalence estimates of diarrhea have been determined every 3 5 years since 1993 using representative national samples from the Bangladesh Demographic and Health Surveys; however, the seasonality of the data collection periods were not harmonized across surveys, therefore direct comparisons cannot be made.
The protocols were harmonized and adjusted in an interlaboratory comparison study among the three P-postlabeling investigator laboratories (Pedersen et al. 2013b) and included the use of external benzo[ a]pyrene-7,8-diol-9,10-epoxide (BPDE)–DNA standard [111 adducts in 10 normal nucleotides (nt)].
The protocols were harmonized and adjusted in an interlaboratory comparison study among the three P-postlabeling investigator laboratories, including the use of the same external benzo[ a]pyrene-7,8-diol-9,10-epoxide (BPDE)–DNA standard [111 adducts in 10 normal nucleotides (nt), which was a kind gift from F.F. Beland (National Center for Toxicological Research, Little Rock, AR, USA)].
Carefully consider the pros and cons of creating harmonized datasets and of drawing direct comparisons between similarly labelled 'groups' in different countries.
Comparison data from trials applying harmonized trial design will lead to optimized immunotherapeutic treatment protocols to maximize clinical efficacy while minimizing toxicity.
To enable international comparison of veterinary antimicrobial consumption data, harmonized units of measurement, animal weights and animal (sub) categories are needed.
The FFQ to collect information on dietary intake was specially designed and harmonized across all sites to allow cross-country comparisons.
