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Using a harmonization strategy (hereby aligning quantitative values to the EARL/EANM harmonizing standards with a proprietary filter, the EQ.PET methodology) either for the pre- or post-treatment scans gave almost perfect agreement levels in comparison with the OSEMPET1/OSEMPET2 reference standard, with narrow confidence intervals.
The European Association Research Ltd EARLL) accreditation program [15] is an SUV harmonization strategy aiming at minimizing the variability in SUV measurements by harmonizing patient preparation and scan acquisition and processing [16].
Impact of the EARL harmonization strategy on MATVs defined by the isocontour and gradient-based delineation methods (observer 2).
Fig. 5 Impact of the EARL harmonization strategy on Dice and concordance indices between MATVs extracted from OSEM images and PSF images (observer 1).
Impact of the EARL harmonization strategy on Dice and concordance indices between MATVs extracted from OSEM images and PSF images (observer 2).
Fig. 3 Impact of the EARL harmonization strategy on MATVs defined by the isocontour and gradient-based delineation methods (observer 1).
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The EORTC and PERCIST classifications would benefit from harmonization strategies such as the EARL accreditation program in multicentre studies or in sites equipped with multiple PET systems.
For this dataset there are still aspects that would benefit from further analysis, such as alternative harmonization strategies of the mentions or a comparative analysis on the performance of systems trained on silver-standard corpora versus gold standard corpora.
Importantly, the benefits of protocols and systems for systematically combining datasets, pairing variables and applying harmonization strategies have been explored previously [ 46].
The vast majority of statistical harmonization strategies in the literature call for at least some overlap in the items administered to assess a given construct.
Therefore, inter-enterprise architecture offers multiple benefits, including: joint process harmonization, business strategy and information technology alignment, technological cost reduction, risk and redundancies reduction, customer services improvement and enhanced responsiveness.
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