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The vast majority of statistical harmonization strategies in the literature call for at least some overlap in the items administered to assess a given construct.
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Previous studies aimed at validating the EARL harmonization strategy in the clinical setting have shown that SUVmax is more sensitive to reconstruction inconsistency than SUVpeak or their lean body mass equivalents, SULmax and SULpeak.
The EORTC and PERCIST classifications would benefit from harmonization strategies such as the EARL accreditation program in multicentre studies or in sites equipped with multiple PET systems.
These spillovers do not affect the legitimacy of unilateral regulation, but they might argue for public and private harmonization strategies to eliminate the spillovers.
The European Association Research Ltd EARLL) accreditation program [15] is an SUV harmonization strategy aiming at minimizing the variability in SUV measurements by harmonizing patient preparation and scan acquisition and processing [16].
Importantly, the benefits of protocols and systems for systematically combining datasets, pairing variables and applying harmonization strategies have been explored previously [ 46].
Impact of the EARL harmonization strategy on MATVs defined by the isocontour and gradient-based delineation methods (observer 2).
Fig. 3 Impact of the EARL harmonization strategy on MATVs defined by the isocontour and gradient-based delineation methods (observer 1).
Fig. 5 Impact of the EARL harmonization strategy on Dice and concordance indices between MATVs extracted from OSEM images and PSF images (observer 1).
Impact of the EARL harmonization strategy on Dice and concordance indices between MATVs extracted from OSEM images and PSF images (observer 2).
In section 2, we examine the reach of the principles of free movement and competition law in social policy, the area of "negative harmonization". In section 3, the focus is on the "positive harmonization" of the social policy Directives, looking at the different approaches adopted by the Community to harmonization in the social sphere.
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