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Several potential factors responsible for the decline in dispersion in Europe are the harmonization of tax rates, convergence of income and labor costs, liberalization of trade and factor markets, and increased coherence of monetary policy.
Subsequent international collaborative studies demonstrated that protocol standardization and establishment and validation of conversion factors (CFs) between field methods and IS Reference Laboratories improved harmonization and MMR concordance rates.
Harmonization does not change the American rate, but does affect some other rates.
Although the intention of the harmonization was to study the prevalence rates of OA across countries and to focus on personal and societal consequences of OA, we cannot pursue these research questions with the current harmonized OA data.
Germany and France have long favored harmonization, complaining that they are undercut by lower rates in countries like Ireland or Slovakia.
But judicial harmonization cannot achieve a fully harmonized system.
The interpretation of the definitions between countries is too diverse and pre harmonization is needed to reliably study cross-national differences in prevalence rates of OA.
The final phase will culminate in a full monetary union, which will imply the adoption of irrevocable fixed exchange rates and a single currency, as well as full harmonization of economic, fiscal and monetary policies by the member states.
The International Conference on Harmonization (ICH) Topic S7A and S7B guidelines only require the assessment of heart rate, blood pressure and the electrocardiogram in nonclinical in vivo safety pharmacology studies.
A code book (harmonization guidelines) was made explaining how the variables were harmonized (see additional file 1: Harmonization guidelines).
Optimization of the protocol for serum-free conditions should result in excellent detection rates and eliminate the requirement of serum batch and stability testing, allowing further harmonization of the assay.
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