The Global Pregnancy Collaboration (CoLab) has promoted harmonization of studies and standardized data collection to facilitate pregnancy and placental research.
The institution of an interactive consortium for a globalized biorepository, high throughput and multidimensional technologies, sophisticated experimental and clinical study design, strong bioinformatics approaches, and harmonization of studies through the implementation of standard operative procedures with voluntary participation might provide cost-effective solutions.
There should be harmonization of study designs, data collection, and analytical procedures, which may require a data coordination center that could also assess data quality and missing data.
EPITARGET is also anticipating the future challenges and requirements in a larger-scale preclinical harmonization of epilepsy studies, including training, data management expertise, cost, location, data safety and continuity of data repositories during and after funding period, and incentives motivating for the use of CDEs.
Post harmonization of epidemiologic studies has become more common in the past 20 years [ 28].
The BiomarCaRE project is designed as a multi-modular study including: (1) biomarker selection based on omics discovery studies as well as literature, and (2) assay development (Module 1), (3) data harmonization of large-scale studies and (4) biomarker determination, analyses and validation (Module 2), and (5) biomarker assessment in clinical trials and (6) economic evaluation (Module 3).
The literature is limited by a lack of harmonization of measures across studies, retrospective designs, and small and idiosyncratic samples.
Interventions and programs have had different goals, mechanisms, and targets, and there has been little harmonization of evaluation across studies [ 38- 40].
Exposing these limitations may improve the design of future research and foster greater harmonization of RA clinical studies that aim to investigate the effects of sequential biologic drug therapies in RA.
Uniform assessment of depression is essential in order to improve efforts at data harmonization across studies of PLWHA.
This harmonization of atlases improves inter-study and longitudinal consistency of segmentations in the subsequent consensus labeling step.
