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61 One of the key factors for clinical development will be the harmonization of outcome measures.
Existing initiatives for harmonization of outcome measurements in asthma trials need urgent implementation.
These recommendations form an excellent starting point for harmonization of outcome measures and accompanying inferential statistical measures in RCTs and other comparative effectiveness research.
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As a consequence, harmonization of the outcome definitions used in our large epidemiologic collaborations will strengthen the consistency of future results.
Though collaboration on PLA negotiation is an extension of collaboration on health technology assessment, it is a very significant next step that requires harmonization of the outcomes of decision-making processes.
Even within geographic regions, as defined in the present study, challenges related to harmonization and validation of outcome measures may occur, potentially further increasing trial data variance [ 40].
Key issues include the need to expand the workforce trained in aging research, development of specific resources and harmonization of measures and outcomes, and a culture change within the scientific community.
CANPWR quality assurance processes have begun with harmonization and review of the methods applied at each site for collection of outcome variables and determinants.
In contrast, research-based interventions, which facilitate harmonization of approaches across key domains such as the outcomes evaluated and reported, are developed based on reports on what was effective in past interventions.
Harmonization of the legal regulations on this issue across Europe would be advisable.
Other areas where research can be fruitfully directed, based on this review, include harmonization of indicators used for assessing health shocks and economic outcomes.
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