These issues highlight the need for the standardization and harmonization of methodologies used for BCR ABL quantification in Ph+ALL.
First, a harmonization of methodologies for airway sample collection, processing and analysis is required to provide comparable datasets.
Recommendations: For better programming, partners need to link up their resources for better harmonization to contribute to better coordination of data during assessment and improved analysis through harmonization of methodologies and approaches by various agencies in capacity building.
Aβ oligomers are thought to exert their harmful effects by binding directly to the membranes of neurons, or to specific receptors needed for neuronal signaling, although more research and also harmonization of the methodology used are needed to fully understand the deleterious effect of Aβ oligomers [ 12- 14].
There is a need for harmonization of scientific methodologies to better evaluate data across different trials, drugs, and patients.
Further harmonization of the laboratory methodology is still needed [ 136].
The clinical relevance of auto-antibodies against Aβ is still unclear, related in part to the urgent need for harmonization of the detection methodologies.
Harmonization of risk factor assessments and methodologies between cohorts should be sought with the aim of enabling integration of a range of cohorts into single large-scale analyses.
Guidelines for the harmonization of response assessment in clinical trials of lymphoma provide a clear definition and methodology for assessing progression but do not address the definition and assessment of nonprogression events [ 15, 19].
The near miraculous harmonization of metabolism required for balanced growth is a classic problem of biology [14] and new methodology promises to reinvigorate its exploration [15], [16].
