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Improvements in the areas of exposure assessment, outcome harmonization, assessment of other congenital anomalies, and mechanistic knowledge are needed to advance this field.
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Based on this description, we are now preparing a protocol according to the standards of the Dutch Harmonization Quality Assessment in Healthcare [ Harmonisatie Kwaliteitsbeoordeling in de Zorgsector].
As the issue of harmonization of risk assessment approaches is debated, it is important to ask what is the primary objective of the risk assessment endeavor.
Hence, the harmonization of habitat assessment methods and reporting formats are a critical issue.
They also point out that these differences create a challenge to the harmonization of the assessment of substances that have the properties of PBTs and/or vPvBs.
Increased harmonization of the assessment procedure may improve the overall process.
Guidelines for the harmonization of response assessment in clinical trials of lymphoma provide a clear definition and methodology for assessing progression but do not address the definition and assessment of nonprogression events [ 15, 19].
Moreover, it should be noted that harmonization of exposure assessment is not straightforward and may not be beneficial in all cases as for example for many exposures there is no gold standard, and questionnaires may be based on wrong hypotheses.
This is a potential area for harmonization as health assessments move towards unifying the cancer and noncancer assessments that could be readily explored by the batch-processing approach explored herein.
As noted above, there was enthusiasm among the workshop participants to continue to work together toward international harmonization of liver safety assessment approaches.
For exposures that are (mainly) assessed by means of biomonitoring (i.e. metals, pesticides, POPs, and other chemical pollutants), the performance of inter-laboratory comparisons and either the harmonization of the exposure assessment with regard to the sampling medium or the development of conversion factors has been recommended to facilitate combined analyses (Table 2).
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