Although first-line ART for children has also been simplified to some extent, further simplification and harmonization between age groups remains challenging, and different approaches are recommended based on age due to available formulations and safety profiles, which vary by age.
Common Databases created during the harmonization process, with 11,557 subjects aged 65-89, will be described.
As original data collection in the consortium was not standardized and comprehensive across all these studies, we accounted for this limitation through thorough data harmonization and restriction to postmenopausal women aged 50 years and older.
The harmonization between controls and patients concerning age, gender, and risk factors was taken into account.
The Integrated Analysis of Longitudinal Studies of Aging collaboration focuses on data harmonization and reproducibility of research from international longitudinal studies focused on aging and health-related change in cognition, health, and well-being [ 70].
The harmonization significantly reduced scanner-related differences in the age trends of ROI volumes, improved longitudinal consistency of segmentations, and resulted in higher across-scanner intra-class correlations, particularly in the white matter.
But judicial harmonization cannot achieve a fully harmonized system.
Participants were divided into pediatric age categories according to the International Conference on Harmonization (ICH) guidelines: neonates (birth 27 days), infants (28 days–23 months), children (2 11 years) and adolescents (12 18 years).
Finally, we conclude by highlighting emerging methodological trends in the study of adult development and aging, including recent emphasis on integrated data analysis and harmonization, as well as adopting an intraindividual variability approach for informing dynamic aging-related processes.
Key issues include the need to expand the workforce trained in aging research, development of specific resources and harmonization of measures and outcomes, and a culture change within the scientific community.
