Furthermore, trials show a substantial lack of quality and harmonisation, resulting in heterogeneous treatment protocols and difficulties when interpreting the findings reported in the literature.
The 2005 Paris Declaration of Aid Effectiveness places local government in the leading seat, calling for ownership, harmonisation, alignment, results and mutual accountability.
To evaluate the sensitivity and harmonisation of results between different laboratories, aliquots of a single DNA preparation were analysed at three Scandinavian laboratories.
The Aid Effectiveness Agenda has roots that extend well before the 2005 declaration of the Paris Principles, with their emphasis on ownership, alignment, harmonisation, managing for results and mutual accountability [ 1].
However, if the relationships between methods, as well as their error structures, were known, this problem could be addressed by use of correction and calibration coefficients, which would allow harmonisation of the results obtained from the different methods.
It is based on five principles intended to make aid more effective: ownership; alignment; harmonisation; mutual accountability; and results.
This independence results in harmonisation challenges, not least lack of uniformity, making it difficult to evaluate care, diagnoses and treatment across the UK.
Moreover, biobanking in European networks will result in harmonisation of health, lifestyle and other exposure data as well as the development and implemention of harmonised definitions of diseases by increased consensus on the criteria for clinical endpoints.
In particular, the Southampton ACSC is the only case where the calibration brings a minor (and not significant) decrease of variability, likely to represent the result of harmonisation of residual equipment-related differences.
"The one bit of a good news is that they result in harmonisation across Europe which is better than the existing situation with 27 different national laws, but the content of some these proposals is very onerous," said Marc Dautlich, head of information law at Pinsent Masons.
