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While the mechanism underlying T cell failure in this context remains unclear, it is known that normally harmless microorganisms that coevolved with humans can help prevent the body from generating inappropriate immune responses.
Pattern recognition receptors expressed on DC and other immune cells contribute to the specific recognition of pathogens as well as harmless microorganisms, e.g. commensals [1], and are thus involved in the subsequent expression of specific genes.
Thus, the system needs to develop a network of regulatory pathways and regulatory T cells (Treg) that stop inappropriate immune attacks on self, harmless allergens and gut contents, including harmless microorganisms (Fig. 1).
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This approach involves introducing into the DNA of the harmless microorganism a gene from a pathogenic organism that encodes an antigen capable of eliciting a protective immune response but not the full-blown disease.
They are both commonly isolated as harmless environmental microorganisms, and are used for food fermentation [ 13].
The dual nature of GBS – with its ability to shift from a harmless commensal microorganism to a life-threatening pathogen – requires the appropriate regulation of virulence factors in response to different environmental conditions encountered in the host.
While ultraviolet light is not as effective as filtering, it renders many microorganisms harmless.
It's harmless to soil microorganisms because it is highly diluted in the soil at about 10 parts per million, he said.
One strategy for developing new live vaccines is to introduce highly immunogenic, but non-pathogenic, epitopes from Mycobacterium tuberculosis (Mtb) into the BCG genome or alternatively to use a mutated Mtb in which at least two virulence genes have been altered so as to render the microorganism harmless [5].
Many of these microorganisms are harmless commensals, but there are also opportunist pathogens.
At the moment, there is lack of evidence regarding the most effective antibiotic agent as treatment response is variable and sometimes even ineffective supporting the hypothesis that these microorganisms are harmless commensals in humans, rendering specific treatment questionable [ 1].
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CEO of Professional Science Editing for Scientists @ prosciediting.com