Part of the help you can get as a heroin addict, for instance, is that you will be allowed to enter a rehab-program where the government provides you with methadone, a much less harmful substitute.
Moreover, the savings in health were predicted to far outweigh cost, and "in the longer perspective, the requirements of REACH may stimulate the development of less harmful substances as substitutes for restricted ones".
You can't tackle one harmful addiction by substituting another, more deadly, one.
The state asked manufacturers to replace harmful chemicals with safe substitutes.
To avoid the aforementioned problems, consumers and authorities have increased pressure on food manufacturers to substitute the harmful artificial additives with alternative, more effective, nontoxic, and natural substances.
The evidence base for the harmful effects caused by substitute alcohol is, however, less developed than that of legally produced alcohols intended for human consumption (Rehm et al., 2007).
Arginine is the most frequently substituted residue in both datasets (AASs and harmful AASs) while the substitutions from alanine and glutamate are less frequent among harmful AASs (Additional file 5: Figures S5 and S6).
But the agreement's success occurred, in large part, because substitutes for the harmful chemicals were readily available and the problem was made vividly clear by satellite measurements.
Since the DPPH radical scavenging activity of the seaweeds in our study is considerable, they could be used as substitutes to replace harmful synthetic antioxidants commonly used in processed food products, such as butylated hydrotoluene (BHT) and butylated hydroxyanisole (BHA), which have been reported to be carcinogenic and tumorigenic at high doses [ 37].
