Sentence examples for harmful modifications from inspiring English sources
The most likely outcome is the acquisition of harmful modifications leading to loss of function (nonfunctionalization).
Usually, such well-conserved regions are under strong selective constraints that prevent harmful modifications.
These segments are hot-spots on the MANBA gene sequence that could most likely undergo harmful modifications due to high frequency of clinically observed mutations in these regions.
Compartmentalizing the reaction networks enables filtering out harmful modifications and therefore it is a prerequisite for accumulating potential beneficial 'adaptations', as demonstrated in [ 19].
In such cases, simply engineering a molecule capable of producing harmful modification to human DNA might provide a viable (and none too difficult) biothreat option.
As well, CRISPR-based approaches could be used to incur disease by inducing harmful genetic modifications in vivo.
Although induced pluripotent stem (iPS) cells can be obtained with the removable PiggyBac transposon system or an episomal system, both approaches still use DNA constructs so that resulting cell lines need to be thoroughly analyzed to confirm they are free of harmful genetic modification.
Furthermore, some of the chemicals used for modification are harmful and can severely pollute the environment.
The changes made to phosphine usage were significant, including the requirement for site-specific fumigant management plans, training and certification requirements, and additional label modifications to reduce harmful exposures.
However, those who presented a lower perceived probability of genetic predisposition to cancer than objective estimates and who received a UV test result were more anxious than those receiving a NU or positive BRCA1/2 test result, suggesting that they misinterpret this gene modification as being harmful, especially as they did not expect such result.
Genome editing is not considered safe, and any genetic modifications – whether beneficial or unintentionally harmful – affect not only the child, but their children and future generations.
