Through the cold war and beyond, the Energy Department and its predecessor agency, the Atomic Energy Commission, denied that workers had received harmful doses of radiation.
In new guidance handed out by Public Health England on how to issue drug alerts, local drug teams are being advised to avoid talking about 'high purity' or 'high potency' drugs, and instead to talk about 'highly harmful doses' of drugs.
Hormesis-stimulating compounds initiate an adaptive stress response that renders cells/organisms resistant against high (and normally harmful) doses of the same agent.
Assessment of different LD50 to THP-1 cells from various compounds provide a determination of the tested compounds safe zone, (the non-harmful dose).
The navy maintains US sailors serving in Japan received only small, non-harmful doses of radiation.
Medical experts, however, said the sailors would have received only small, non-harmful doses of radiation; a US defence department report published in 2014 said no link had been established between the sailors' health problems and their exposure to low doses of Fukushima radiation.
Although the possibility that some persons might not have sufficient time to accumulate a harmful lifetime dose up to the age of 50 years, we consider the evidence of no clinically important association between analgesic use and ESRD provided by this study to be the best currently available.
The answer to the question posed above will therefore have to wait for the completion of this study, but in the mean time I suggest that doses greater than 1,000 μg/day could be harmful and doses less than 800 μg/day may not be optimal in critically ill patients.
She says the patients most at risk of opioid-related harms are those with mental health or substance use disorders who have greater odds of both being prescribed opioids and getting them in harmful high doses.
