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Much of the harm was found to be the responsibility of the United Nations Interim Administration Mission (Unmik) and the government of Kosovo.
Suggestion of potential harm was found, with some (non-randomised) studies reporting an increase in cancer-related distress.
After adjusting for propensity to transfuse, no significant benefit or harm was found from RBC transfusion in these patients at 30 days (OR, 0.64; P = 0.17; CI, 0.34 to 1.2) or at 1 year (OR, 1.02; P = 0.95; CI, 0.61 to 1.69).
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Cost would be considered primarily where no clinically important differences in benefit or harm were found.
The TSC and trial sponsor have the authority to stop the trial if any indication of harm is found.
Suicide attempts are strongly associated with psychiatric disorder, 39 40 and it is notable that more than three quarters (77%) of participants with suicidal self harm were found to have a history of probable depression.
Furthermore, parents whose child had a previous history of self harm were found to have higher levels of psychological distress so perhaps the SPACE programme would be particularly beneficial to these individuals.
If only a smaller fraction of the alcohol related injuries can be attributed to this small group of high risk individuals whereas the bulk of the harm is found among the majority of drinkers with less individual risk, it is generally argued that prevention strategies targeting the entire population of drinkers are more adequate [ 5, 6].
3 4 During the 1970s, wide variation in the management of patients with self-harm was found in 10 psychiatric teams in one English city.
For example, non-suicidal deliberate self-harm was found to predict suicidal behaviour after controlling for depression [ 9, 13, 14], previous suicidal behaviour [ 13], hopelessness and symptoms of borderline personality disorder [ 14].
Prisoners who self-harmed were found to be at "substantially greater" risk of suicide than other inmates, particularly among men.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com