Considering all the possible trajectories from an initial state leads to the definition of vulnerability indicators as statistics derived from the probability distribution of harm values.
A decision rule recommends treatment when the predicted benefit exceeds the predicted harm, value-adjusted.
Comparing the individualised predictions for the benefit and the harm, value-adjusted, we then obtained individualised treatment recommendations for warfarin.
This 'non-inferiority margin' is the maximum loss of efficacy that is considered acceptable in exchange for a hypothesised reduction in harm, value-adjusted.
The required size of the ARRtarget that offsets the treatment harm, value-adjusted, for the patient i can be calculated as (Appendix section 1, equations (1) and (2)) (m1) The equation includes the particular condition of a fixed harm when the ARItrial can substitute for the ARIi.
A recommendation to treat with the non-inferior therapy would result when the predicted reduction in harm, value-adjusted, exceeds the predicted loss of efficacy, that is, when ARRharm(i) × RVharm/target(i) > ARItarget(i) (or, holding the same terminology as for superiority trials, when predicted ARRharm(i) > required ARRharm(i)).
But some residents say they worry that the treatment plant would harm the value of homes and that regulations would not be followed.
They, too, have little interest in seeing any modification because it would harm the value of their holdings and reduce their income from fees.
WITH sincere apologies to Roseanne Roseannadanna, when it comes to events that can harm the value of your investments, it's always something.
Now that many share prices are falling, options will harm the value of a company's shares even more than they did when stocks were higher, Mr. McGurn of Institutional Shareholder Services said.
